Detection ofDepressed Ventilatory Drive in Patients with Obstructive Pulmonary Disease
نویسنده
چکیده
Impaired pulmonary mechanics or depression of the respiratory centers can limit the ventilatory response to inhaled carbon dioxide in patients with chronic obstructive pulmonary disease (COPD). We devised a method able to detect depressed neurogenic and chemical ventilatory drive during expiratory airflow obstruction. In 14 normal subjects, we impeded expiratory airflow while measuring the resultant decline in maximum voluntary ventilation (MVV) and the ventilatory response to rebreathing 7 percent CO, ( / Pco2). The MVV and / Pco2 fell proportionately and were closely correlated (r 0.88). The lower limit for
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